Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Calcium Channel - Bay K-8644

Bay K-8644

CAS No. 71145-03-4

Bay K-8644( Bay K8644 )

Catalog No. M15726 CAS No. 71145-03-4

Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 43 Get Quote
5MG 72 Get Quote
10MG 115 Get Quote
25MG 237 Get Quote
50MG 374 Get Quote
100MG 556 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Bay K-8644
  • Note
    Research use only, not for human use.
  • Brief Description
    Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM.
  • Description
    Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM, has positive inotropic, vasoconstrictive and behavioral effects in vivo; enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts (MEFs) to induce pluripotent stem cells (iPSCs) combination with BIX-01294.
  • In Vitro
    In newborn rat ventricular cardiomyocytes, Bay K 8644 (1 μM) treatment increases L-type calcium current density in 2-day-old cells. The higher increase of L-type calcium current density by Bay K 8644 in 2-day- than in 7-day-old cultured cells could be interpreted as the result of a difference in the phosphorylation level of calcium channels for each stage of development.
  • In Vivo
    A one time dose as low as 10 μg/kg of Bay K 8644 significantly elevates mean arterial pressure (MAP) in endotoxin-treated hypotensive rats while having minimal effects in normal rats. Bay K 8644 also causes a dose-dependent decrease in heart rate of 37% in endotoxin-treated rats and 39% in control rats.
  • Synonyms
    Bay K8644
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    L-type calcium channel
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    71145-03-4
  • Formula Weight
    356.3
  • Molecular Formula
    C16H15F3N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (233.88 mM)
  • SMILES
    O=C(C1=C(C)NC(C)=C([N+]([O-])=O)C1C2=CC=CC=C2C(F)(F)F)OC
  • Chemical Name
    1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang W, et al. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32. 2. Greenberg DA, et al. Brain Res. 1984 Jul 9;305(2):365-8. 3. Bourson A, et al. Eur J Pharmacol. 1989 Feb 7;160(3):339-47.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • BMS-195270

    BMS-195270 is a tissue-specific inhibitor of bladder muscle tone and spontaneous contraction in rats. It can inhibit Carbachol-induced tone and inhibit calcium flux in isolated rat bladder tissue strips in an isolated bladder model.

  • Gallopamil hydrochlo...

    Gallopamil hydrochloride is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies.

  • Clevidipine

    A dihydropyridine L-type calcium channel blocker, highly selective for vascular and has little or no effect on myocardial contractility or cardiac conduction.

Sign In Join Free