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Home - Products - GPCR/G Protein - Calcium Channel - Bay K-8644

Bay K-8644

CAS No. 71145-03-4

Bay K-8644( Bay K8644 )

Catalog No. M15726 CAS No. 71145-03-4

Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Bay K-8644
  • Note
    Research use only, not for human use.
  • Brief Description
    Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM.
  • Description
    Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM, has positive inotropic, vasoconstrictive and behavioral effects in vivo; enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts (MEFs) to induce pluripotent stem cells (iPSCs) combination with BIX-01294.
  • In Vitro
    In newborn rat ventricular cardiomyocytes, Bay K 8644 (1 μM) treatment increases L-type calcium current density in 2-day-old cells. The higher increase of L-type calcium current density by Bay K 8644 in 2-day- than in 7-day-old cultured cells could be interpreted as the result of a difference in the phosphorylation level of calcium channels for each stage of development.
  • In Vivo
    A one time dose as low as 10 μg/kg of Bay K 8644 significantly elevates mean arterial pressure (MAP) in endotoxin-treated hypotensive rats while having minimal effects in normal rats. Bay K 8644 also causes a dose-dependent decrease in heart rate of 37% in endotoxin-treated rats and 39% in control rats.
  • Synonyms
    Bay K8644
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    L-type calcium channel
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    71145-03-4
  • Formula Weight
    356.3
  • Molecular Formula
    C16H15F3N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (233.88 mM)
  • SMILES
    O=C(C1=C(C)NC(C)=C([N+]([O-])=O)C1C2=CC=CC=C2C(F)(F)F)OC
  • Chemical Name
    1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang W, et al. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1427-32. 2. Greenberg DA, et al. Brain Res. 1984 Jul 9;305(2):365-8. 3. Bourson A, et al. Eur J Pharmacol. 1989 Feb 7;160(3):339-47.
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